Buffalo Translational Consortium News

Summer Research Fellowships Awarded to Six UB Medical Students

Posted on 05/23/12 at 09:26 am

A T35 Training Grant from the NIH jointly awarded to UB and Roswell Park will support research fellowships to 6 UB medical students to perform 10 week summer fellowships in the laboratories of UB and Roswell Park faculty in the areas of infectious diseases, microbiology and immunology.  A total of 27 applications were received for 6 positions. Based on a rigorous review by a Steering Committee of faculty and educational leaders, fellowships were awarded for the summer of 2012.

The following students were awarded fellowships and chose faculty mentors.

Student Fellow             Faculty Mentor
Moyukh Ghosh                Sandra Gollnick PhD
Aleksandr Kalininskiy       Mark O’Brian PhD
Chinelo Ogbudinkpa         Amy Jacobs PhD
Christopher Sciria            Thomas Russo MD CM
Lauren Schmidt               Anthony Campagnari PhD
Matthew Stevens             Elizabeth Repaskey PhD

The program includes:
•    A mentored research project
•    A weekly seminar series
•    Laboratory practical sessions
•    Training in the responsible conduct of research.
•    Oral presentations by students at the end of the summer program
•    Poster presentations by students at an annual research day.

Co-Principal Investigators are Timothy F. Murphy MD, Senior Associate Dean for Clinical and Translational Research in the UB School of Medicine and Kelvin Lee MD, Chair, Department of Immunology and Vice Chair, Department of Medicine at Roswell Park.  

PET/CT Scanner Installed in Clinical and Translational Research Center

Posted on 03/26/12 at 10:31 am

An NIH Shared Instrumentation grant (Principal Investigator John Canty MD) supported a new GE Discovery PET/CT 690 which was recently installed in the Imaging Center on the 7th floor of the CTRC. This state of the art instrument, dedicated exclusively for research purposes, will advance preclinical and clinical translational molecular imaging. Investigators in the Center for Research in Cardiovascular Medicine and the Toshiba Vascular Research Center are among the first groups that will move into the CTRC and utilize the scanner. Once the scanner is operational, it will be available for use by investigators in the Buffalo Translational Consortium.  An excellent feature of this scanner is the flexibility to expand to the future generation of disease specific tracers, to diagnose and monitor more diseases, and to explore the efficacy of novel treatments.

Pilot Studies Grants in Clinical and Translational Research Awarded

Posted on 03/20/12 at 09:40 am

A total of 44 proposals in response to the two Requests for Applications were received. Applicants included faculty from throughout the Buffalo Translational Consortium. The following offices contributed a total of $200,000 in support.

  •     Office of the Vice President for Research
  •     Office of the Vice President for Health Sciences
  •     Roswell Park Cancer Institute
  •     Dean, School of Medicine and Biomedical Sciences
  •     Dean, School of Public Health and Health Professions
  •     Dean, School of Nursing
  •     Dean, School of Dental Medicine
  •     Dean, School of Pharmacy and Pharmaceutical Sciences

After a first round of rigorous peer review led by Dr. Kenneth Tramposch, the Pilot Studies Oversight Committee, chaired by Drs. Steven Fliesler and Leonard Epstein, evaluated the proposals.  As outlined in the RFA, an important review criterion was the likelihood that work supported by Pilot Studies would lead to major extramural funding.

The Principal Investigators of the Pilot Studies that were awarded (see below) will present their work at the Second Annual Clinical and Translational Research Colloquium, which will be held in the Fall of 2012 at the Clinical and Translational Research Center.

The following 6 projects were chosen to receive funding:

Multifunctional Optical Imaging Probe for Cutaneous Chronic Graft versus Host Disease Lesions

  • Chulhong Kim, Ph.D. Department of Biomedical Engineering, University at Buffalo,
  • George Chen, M.D., Philip McCarthy, MD, Theresa Hahn, PhD, Hong Liu, MD, PhD, Maureen Ross, MD, PhD, Department of Medicine, Roswell Park Cancer Institute
  • Paul Bogner, MD, Department of Pathology, Roswell Park Cancer Institute
  • Greg Wilding, PhD, Department of Biostatistics, Roswell Park Cancer Institute

Novel Multiplex Autoantigen Arrays for Biomarker Discovery in Skin Autoimmunity

  • Animesh A. Sinha, M.D., Ph.D., Kristina Seiffert-Sinha, M.D., Department of Dermatology University at Buffalo and Roswell Park Cancer Institute
  • Norma J. Nowak, Ph.D., University at Buffalo and Roswell Park Cancer Institute
  • Song Liu, Ph.D., Department of Biostatistics, Roswell Park Cancer Institute
  • Richard W. Plunckett, Ph.D., Raminder Grover, M.D., Beutner Labs, Inc.

Anthracycline-related Cardiomyopathy in Breast Cancer Patients: Impact of Carbonyl Reductase 3 Genotype Status on Echocardiographic Measurements of Cardiomyopathy

  • Javier G. Blanco, PhD, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo
  • Tracey O’Connor, MD, Department of Medicine, Roswell Park Cancer Institute
  • Vijay Iyer, M.D, Department of Medicine, University at Buffalo

Adapting Photodynamic Therapy into a Novel Treatment for Bacterial Infections

  • Anthony Campagnari, Ph.D., Nicole Luke-Marshall, Ph.D., Department of Microbiology and Immunology, University at Buffalo
  • Thomas Russo, M.D., C.M., Department of Medicine, University at Buffalo
  • Thomas Mang, Ph.D., Department of Oral and Maxillofacial Surgery, School of Dental Medicine University at Buffalo

Overcoming Myeloid Cell-Mediated Immunosuppression to Enhance Vaccine Efficacy in Ovarian Cancer

  • Brahm H. Segal, MD. Department of Medicine, Roswell Park Cancer Institute and University at Buffalo
  • Scott Abrams, PhD, Department of Immunology and Kunle Odunsi, MD, PhD, Department of Gynecologic Oncology, Roswell Park Cancer Institute.

 One Size Fits All” Vascular Graft – Tissue Engineered Vasculature

  • Daniel D. Swartz, PhD, Department of Pediatrics, University at Buffalo
  • Stelios T. Andreadis, PhD, Department of Chemical and Biological Engineering, University at Buffalo

UB and Kaleida Schedule Ribbon Cutting and Grand Opening

Posted on 02/19/12 at 09:27 am

Kaleida Health and the University at Buffalo have teamed up to build a state of the art facility on the Buffalo Niagara Medical Campus.

The $291million, 10-story building is a first-of-its-kind for Buffalo, bringing  together under one roof clinical care, translational research, and business incubation. The building will house two independent and cooperative entities:

  • Gates Vascular Institute which merges Kaleida’s cardiac, stroke and vascular operations plus a new expanded emergency department.
  • UB Clinical and Translational Research Center (CTRC) which is a 170,000 square foot research center that will be the hub of clinical and translational research in the region. 

The CTRC will also house the Jacob’s Institute, established in honor of Dr. Lawrence Jacobs to support research and clinical collaboration to study vascular disease, and the UB Biosciences Business Incubator to support start up companies involved in translational research.

Kaleida’s expanded emergency department opened in November 2011.  Clinical operations of the Gates Vascular Institute will commence in late March 2012.

The UB Clinical and Translational Research Center will open in May 2012 and researchers will move their laboratories into the building during the summer. The CTRC will also house translational research programs of new faculty who will be recruited to Buffalo over the next couple of years.

A Ribbon Cutting for the building, including the Gates Vascular Institute and the CTRC is scheduled for May 24.  A Grand Opening for the CTRC is scheduled for September 20, 2012.

This news item from YNN highlights the UB-Kaleida partnership and gives an overview of the CTRC.

Read this UB Reporter article to learn about the programs supported and conducted by the CTRC.

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