Buffalo Translational Consortium News
Dr. Sanjay Sethi, Professor of Medicine and Chief of the Division of Pulmonary, Critical Care and Sleep Medicine has been appointed Assistant Vice President for Health Sciences and Medical Director of the UB Clinical Research Office. Dr. Sethi is an internationally recognized clinical researcher in the area of chronic obstructive pulmonary disease (COPD), having led many clinical trials, including multicenter international trials. He was named one of the top 5 researchers in COPD nationally by Expertscape in 2013.
The university-wide Clinical Research Office (CRO) located adjacent to the Clinical Research Center on the sixth floor of the CTRC is steadily growing in staff and capacity. The CRO is a centralized office that functions to streamline and support researchers in performing their clinical research, providing assistance with:
- IRB and Regulatory Document Preparation
- Protocol Development and Review
- Contract Negotiation
- Budget Negotiation
- Accounts Receivable/Accounts Payable Set-up
- Coverage Analysis Review
- Clinical Research Coordinator Support
Over the next several months, the CRO will be implementing a Clinical Trials Management System, which will improve the quality and efficiency of clinical research at UB substantially.
Dr. Sethi will provide leadership and vision as the CRO continues to grow and expand its capacity to support clinical research.
Students who participated in 10 different summer research programs at University at Buffalo, Roswell Park Cancer Institute and the Hauptman Woodward Institute took part in a day-long program at the CTRC on August 1, 2014. In an enormously successful event, attended by ~120 people, the students presented their biomedical research projects in poster format and in oral presentations.
The program featured a total of 97 posters and 8 oral presentations by student trainees.
Lively poster sessions afforded students the opportunity to present and discuss their research with student colleagues and faculty. The undergraduate and professional graduate students who participated were supported by these programs:
• CLIMB UP for Summer Research at UB
o ASPET Summer Undergraduate Research Fellowship (SURF) Program
o Institute for the Strategic Enhancement of Educational Diversity (iSEED)
o CLIMB PRO
o BioXFEL Summer Undergraduate Experience (BSURE)
• Summer Undergraduate Research Program (SURE) at the UB School of Medicine and Biomedical Sciences
o Brain Network of Excellence (BNE) Summer Scholars Program
• UB School of Dental Medicine Student Research Program
• Roswell Park Summer Research Experience Program in Cancer Science
• T35 Research Program in Infectious Diseases, Microbiology and Immunology at the UB School of Medicine and Biomedical Sciences and Roswell Park
• Hauptman-Woodward Research Institute Summer Apprentice Program
Dr. Anthony Campagnari gave an insightful and entertaining talk about early influences as he began his long and productive career in research.
Pilot Studies in translational research were awarded to 6 groups of faculty researchers from Buffalo Translational Consortium institutions. The awards, totaling ~$200,000, were made possible by broad-based contributions from the following offices:
• Office of the Vice President for Health Sciences
• Office of the Vice President for Research
• Roswell Park Cancer Institute
• Dean, School of Medicine and Biomedical Sciences
• Dean, School of Dental Medicine
• Dean, School of Pharmacy and Pharmaceutical Sciences
• Dean, School of Engineering and Applied Sciences
• Dean, School of Public Health and Health Professions
• Dean, School of Nursing
A total of 51 applications were received and underwent a rigorous 2-tiered review process. The first round of scientific review was coordinated by Dr. Kenneth Tramposch, Associate Vice President for Research, who convened 6 expert review panels. The Pilot Studies Oversight Committee, co chaired by Drs. Steven Fliesler and Leonard Epstein conducted a second level of review and made final decisions on funding (committee members with proposals under consideration did not participate). An important review criterion was that the pilot awards will lead to larger extramural awards to grow our portfolio of translational research.
The following 6 proposals were awarded:
Biomarkers for detection of treatment response and disease recurrence in pancreatic cancer
• Robert Straubinger PhD, Jun Qu PhD, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences
• Wen Wee Ma MBBS, Department of Medicine, Roswell Park Cancer Institute
• Elizabeth Repasky PhD, Department of Immunology, Roswell Park Cancer Institute
Senescence as a stimulus for inflammation
• Thomas Cimato MD PhD, Department of Medicine, School of Medicine and Biomedical Sciences
• Andrei Gudkov PhD Dsci, Department of Cell Stress Biology, Roswell Park Cancer Institute
• Paul Wallace PhD, Department of Flow and Image Cytometry, Roswell Park Cancer Institute
Vibration powered leadless cardiac pacemaker
• Amin Karami PhD, Department of Mechanical and Aerospace Engineering, UB School of Engineering and Applied Sciences
• Vijay Iyer MD, Department of Medicine, School of Medicine and Biomedical Sciences
Human fibrotic microtissue chips for screening of anti-fibrotic therapies
• Ruogang Zhao PhD, Stelios Andreadis PhD, Department of Biomedical Engineering, School of Engineering and Applied Sciences and School of Medicine and Biomedical Sciences
Use of cardiac MRI and tissue characterization to identify the morphology of myocardial scar and high-risk peri-infarct region
• Umesh Sharma MD PhD, John Canty MD, Gen Suzuki MD PhD, Department of Medicine, School of Medicine and Biomedical Sciences
• Leslie Ying PhD, Department of Biomedical Engineering, School of Engineering and Applied Sciences and School of Medicine and Biomedical Sciences
Expression-based biomarkers in cystic fibrosis
• James Jarvis MD, Drucy Borowitz MD, Department of Pediatrics, School of Medicine and Biomedical Sciences
• Yijun Sun PhD, Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences
Pilot Studies award winners will present their work at the Clinical and Translational Research Colloquium to be held in 2015 at the Clinical and Translational Research Center.
Click this link for past colloquia.
In an effort to enhance communication and collaboration opportunities among researchers in the CTRC and to recognize the outstanding research productivity of research groups, we will periodically post publications by groups based in the CTRC as news items.
The attached list includes 84 publications and 6 textbook chapters by CTRC researchers and trainees from January 1, 2013 through May 1, 2014. The papers include:
- Original articles in peer-reviewed journals
- Review articles
The work encompasses a wide range of disciplines with a common translational theme.
Congratulations to all!
Click this link for the publications by each of the research groups.