Buffalo Translational Consortium News

2017 Creative Scientist Workshop

Posted on 02/17/17 at 01:34 pm

  

Innovations in Recruitment to Clinical Trials

March 14-15, 2017
Embassy Suites
200 Delaware Avenue
Buffalo, NY 14202

Registration and hotel reservation

Current agenda

To encourage participation from a wide range of CTSAs, we will reimburse the registration cost for the first registrant from each CTSA hub.

Discuss and develop novel approaches to clinical trials in a unique, collaborative environment

Registration and hotel reservations are now available for the 2017 Creative Scientist Workshop sponsored by the State University of New York at Buffalo Clinical and Translational Science Institute (CTSI) with ongoing input from the National Center for Advancing Translational Sciences (NCATS). This year’s workshop is focused on developing collaborative proposals to address the number one obstacle to successful clinical trials: recruitment of participants.

The Creative Scientist Workshop is not a standard conference. The facilitated workshop format employs a creative problem-solving approach now being used by NSF, NIH and NCATS to catalyze scientific innovation. Workshop attendees will frame the problem space from diverse perspectives and present and discuss a range of innovative case studies and potential best practices.

Most importantly, our deliberate focus on creative problem-solving is designed to catalyze the generation of promising novel solutions and to promote the early development of innovative, transdisciplinary, multi-CTSA grant proposals to NCATS.

As a participant, you will:

  • Learn state-of-the-art approaches from throughout the CTSA network and from experts in completely different fields, such as behavioral economics and marketing
  • Share your own experience
  • Form new collaborative teams around promising, innovative grant proposals
  • Advance the evaluation and dissemination of best practices in clinical trials recruitment

CTSI scientists author widely read insecticide study

Posted on 02/16/17 at 09:19 am

 

Common insecticides mimic melatonin, creating higher potential risk for diabetes and metabolic diseases

Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks, University at Buffalo researchers have found. The research suggests that exposure to these insecticides adversely affects melatonin receptor signaling, creating a higher risk for metabolic diseases such as diabetes.

Published online on Dec. 27 in Chemical Research in Toxicology, the research combined a big data approach, using computer modeling on millions of chemicals, with standard wet-laboratory experiments. It was funded by a grant from the National Institute of Environmental Health Sciences, part of the National Institutes of Health.

Altmetric -- a service which collects mentions in media sites, newspapers, policy documents, blogs, Wikipedia and other on-line sources -- ranks the paper in the top 5 percent of all research outputs it has scored. The paper is in the 99th percentile of research outputs published at the same time, and it's one of the highest-scoring outputs from Chemical Research in Toxicology (#2 out of 865) as measured by Altmetric.

Old suspects find new mechanisms to alter human health

The study was funded to pinpoint new environmental diabetogens (chemicals that can cause diabetes) and obesogens (chemicals that can cause obesity). Research on them is “a relatively new research area,” said Raj Rajnarayanan, PhD, lead author on the paper and assistant professor of pharmacology and toxicology at UB.

“Not all insecticides are bad for us,” Rajnarayanan said. “However, it is imperative to study the chemicals that are extensively in use, especially the ones that can get into our air, food, and water.”

Insecticide compounds implicated in circadian activity disruption

Disruptions in human circadian rhythms are known to put people at higher risk for diabetes and other metabolic diseases but the mechanism involved is not well-understood.

“This is the first report demonstrating how environmental chemicals found in household products interact with human melatonin receptors,” said Margarita L. Dubocovich, PhD, senior author on the paper and SUNY Distinguished Professor in the Department of Pharmacology and Toxicology and senior associate dean for diversity and inclusion in the Jacobs School of Medicine and Biomedical Sciences at UB.

“No one was thinking that the melatonin system was affected by these compounds, but that’s what our research shows,” she said.

The current research focuses on two chemicals, carbaryl, the third most widely used insecticide in the U.S. but which is illegal in several countries, and carbofuran, the most toxic carbamate insecticide, which has been banned for applications on food crops for human consumption since 2009. It is still used in many countries, including Mexico and traces persist in food, plants and wildlife.

“We found that both insecticides are structurally similar to melatonin and that both showed affinity for the melatonin, MT2 receptors, that can potentially affect glucose homeostasis and insulin secretion,” said Marina Popovska-Gorevski, co-author, now a scientist with Boehringer Ingelheim Pharmaceuticals, who worked in Dubocovich’s lab while earning her master’s degree at UB. “That means that exposure to them could put people at higher risk for diabetes and also affect sleeping patterns.”

Directions for future research

The results suggest that there is a need to assess environmental chemicals for their ability to disrupt circadian activity, something which is not currently being considered by federal regulators. The UB researchers are developing a rapid bioassay that might be able to assess environmental chemicals for this kind of activity.

The work is part of a larger effort by researchers in the laboratories of Dubocovich and Rajnarayanan to develop their Chem2Risk pipeline, combining UB’s expertise in computational biology and melatonin receptor pharmacology.

“Our approach seamlessly integrates the screening of environmental chemicals through computer simulation, in vitro and in vivo techniques to gauge the risk these chemicals present for various disease end points,” explained Rajnarayanan.

Listen to a podcast of UB's Raj Rajnarayanan, PhD, discussing the significance of the research.

The UB database contains about four million chemicals reported to have some level of toxicity. “From those, we identified hundreds of thousands of compounds that had readily available chemical structures so that we could study them,” Rajnarayanan explained. After grouping the chemicals in clusters according to their similarity, they found several with functional groups similar to melatonin.

Using predictive computational modeling and in vitro experiments with cells that express human melatonin receptors, they found that carbamates selectively interact with a melatonin receptor. That interaction can disrupt melatonin signaling and alter important regulatory processes in the body.

“By directly interacting with melatonin receptors in the brain and peripheral tissues, environmental chemicals, such as carbaryl, may disrupt key physiological processes leading to misaligned circadian rhythms, sleep patterns, and altered metabolic functions increasing the risk for chronic diseases such as diabetes and metabolic disorders,” said Dubocovich.

For example, she explained, there is a fine balance between the release of insulin and glucose in the pancreas at very specific times of day, but if that balance becomes disrupted over a long period of time, there is a higher risk of developing diabetes.

Read the paper here: Carbamate Insecticides Target Human Melatonin Receptors. Marina Popovska-Gorevski et al. Chem. Res. Toxicol. (2016)

Dubocovich is an internationally renowned authority on the brain hormone melatonin and how melatonin receptors are regulated. Her work has significantly boosted the scientific understanding of how melatonin impacts circadian rhythms and human health in general, including sleep disorders, metabolic disease and drug addiction.

Popovska-Gorevski presented preliminary findings on this work at the 2014 Experimental Biology meeting in San Diego, receiving a Best Abstract Award from the Toxicology Division of the American Society for Pharmaceutical and Experimental Therapeutics and a Best Poster Award from the Upstate New York Pharmacology Society.

Community of Scholars Professional Development Series presents overview of Drug Development core

Posted on 02/09/17 at 04:27 pm
Drug Development Core Director Gene D. Morse, PharmD, FCCP, BCPS

 

Role of the Drug Development Core in the UB Clinical and Translational Science Institute

The main objective of the University at Buffalo Clinical and Translational Science Institute (CTSI) Drug Development core is to foster innovation in drug development and clinical therapeutics research. While providing expert mentoring for researchers from the Buffalo Translational Consortium, the core also collaborates with industry partners, arranges access to CTSI core laboratory facilities that specialize in drug development, and helps investigators to prepare a top-flight grant application or cutting-edge research protocol. 

Drug Development Core Director Gene D. Morse, PharmD, FCCP, BCPS, SUNY Distinguished Professor in the UB School of Pharmacy and Pharmaceutical Sciences Department of Pharmacy Practice, will present an overview outlining some of the services and resources the core provides to investigators on Wednesday, February 22, 12 - 1 p.m., in 339 Cary Hall, South Campus, UB.

Registration for this event is due February 19.

 

Contact: Shaweta Gupta, PhD (.(JavaScript must be enabled to view this email address)) or 716-829-6268

Contact Shaweta Gupta, PhD, at .(JavaScript must be enabled to view this email address) or 716-829-6268 formore information.

 

Introducing the University at Buffalo Clinical and Translational Science Institute

Posted on 02/03/17 at 08:31 am
A well-placed Buffalo News story put the spotlight on UB’s Clinical and Trans- lational Science Institute.

   

UB-led consortium that earned prestigious National Institutes of Health grant moves into a new phase

In August of 2015, a University at Buffalo-led consortium of Western New York academic, health care and research institutions and community partners won a prestigious $15 million award from the National Institutes of Health to help expedite the translation of basic biomedical research in the region into practical health care benefits for the community.

As of February 2017, that entity will be known as the University at Buffalo Clinical and Translational Science Institute (CTSI).

The new identity was first revealed in a profile of the CTSI published by The Buffalo News on January 29. It was formally introduced to the UB community during the 2017 State of the School address delivered by Vice President for Health Sciences and Dean of the Jacobs School of Medicine and Biomedical Sciences Michael E. Cain, MD, and in a story that ran in UBNow, the home of campus news for the university.

The adoption of the new name and visual identity is intended to represent the collaborative and scientific mission of the institute. The CTSI’s new logo features the UB logo and is consistent with the new brand and identity strategy launched by the university in 2016. The announcement is coupled with the launch of the @BuffaloCTSI Twitter account, which will provide updates on developments at the CTSI and in translational science generally.

“The change in our name to the Clinical and Translational Science Institute is a better reflection of the innovative clinical and translational work we are engaged in,” said Timothy F. Murphy, MD, SUNY Distinguished Professor in the UB Department of Medicine, senior associate dean for translational research in the Jacobs School of Medicine and Biomedical Sciences, and the institute’s director. “It is intensely focused on groundbreaking research, new discoveries and providing patients with access to innovative, new treatments and therapies.”

The tagline for the CTSI is: Advancing research discoveries to improve health for all. “This statement fully reflects the CTSI mission,” said Murphy. “There have been unprecedented advances in medical research in the last few decades, but it takes too long to translate those discoveries into tangible health benefits. The Buffalo CTSI embodies a regional commitment to maximizing the return on our area’s investment in medical research, based on the principle that the best health care goes hand in hand with the best science.”

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