Buffalo Translational Consortium News

CTSI well-represented at annual ACTS Translational Science conference in D.C.

Posted on 05/15/17 at 01:08 pm

Shown in photo: Sebastian G. Ciancio, DDS, Distinguished Service Professor, Chair, Department of Periodontics and Endodontics, School of Dental Medicine (left) and Jessie Polanco, PhD student, CTSI Diversity Supplement, Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences (right)

More than 20 UB faculty and staff members were on hand to represent the Clinical and Translational Science Institute (CTSI) at the Translational Science 2017 conference held in Washington, D.C., April 19-21.

Organized by the Association for Clinical and Translational Science, the stated purpose of the meeting is to “bring together all of the disciplines involved in clinical and translational research, for the shared benefits of networking and education.”

UB’s attendees conducted nine poster presentations, and two were invited for Distinguished Oral Presentations by conference organizers:

(As published in the Translational Science 2017 Onsite Program with the assigned poster or presentation numbers. UB personnel who attended are italicized.)

28 Prescription Opioid Dependence in Western New York: Using Data Analytics to Find an Answer to the Opioid Epidemic

Shyamashree Sinha, Gale Burstein, Kenneth Leonard, Timothy Murphy, Peter Elkin

46 Increased Galectin-3 Expression after Acute Myocardial Infarction is Strongly Associated with Cardiac Inflammation, Fibrosis and Subsequent Development of Major Cardiovascular Events

Umesh Sharma, Wassim Mosleh, Milind, Guadhari, Gen Suzuki, Saraswati Pokharel, John Canty

Another submission from UB’s delegation received the ACTS Burroughs Wellcome Fund Travel Award:

A31 Muscarinic receptor M3R signaling prevents efficient myelin repair by human and mouse oligodendrocyte progenitor cells

Jessie Polanco, R. Ross Welliver, Richard Seidman, Anjali Sinha, Melanie O’Bara, Zainab Khaku, Fraser Sim

Presenting posters at the conference were:

A209 PTSD: Understanding Differences in Trauma Cognitions, Memory and Emotional Regulation

Ellen Volpe, Tiffany Jenzer, Lauren Rodriguez, Jennifer Read

B181 A Path Perspective on Bio-psychosocial Predictors of Health Status in Peripheral Arterial Disease

Nikhil Satchidanand, Jeffrey Fine, Gregory Cherr

B95 Pretreatment Peripheral Blood Monocyte Gene Expression Signature is Predictive of Patient Response to Dendritic Cell Vaccination for Metastatic Renal Cell Carcinoma

Jason Muhitch, Anand Sharda, Alexander Wald, Mohammad Habiby Kermany, Katja Koppen, Thomas Hampton, Jan Fisher, Camilo Fadul, Marc Ernstoff, Thomas Schwaab

A45 Estimating Microscopic Structures of Glomeruli in Renal Pathology

Pinaki Sarder, Rabi Yacoub, John Tomaszewski

A132 Best Practices for Social and Behavioral Research: A New Course to Address Good Clinical Practice and Preliminary Course Evaluation

Susan Lynn Murphy, Christy Byks-Jazayeri, Brenda Eakin, Jordan Hahn, Brandon Lynn, Elias Samuels, Fanny Ennever, Sarah Peyre, Margarita Dubocovich, Wajeeh Bajwa

A53 High Throughput Phenotype and the Increased Risk of OSA in Rosacia Patients

Peter Elkin, Sarah Mullin, Sanjay Sethi, Shyamashree Sinha, Animesh Sinha

28 Prescription Opioid Dependence in Western New York: Using Data Analytics to Find an Answer to the Opioid Epidemic

Shyamashree Sinha, Gale Burstein, Kenneth Leonard, Timothy Murphy, Peter Elkin

46 Increased Galectin-3 Expression after Acute Myocardial Infarction is Strongly Associated with Cardiac Inflammation, Fibrosis and Subsequent Development of Major Cardiovascular Events

Umesh Sharma, Wassim Mosleh, Milind, Guadhari, Gen Suzuki, Saraswati Pokharel, John Canty

A31 Muscarinic receptor M3R signaling prevents efficient myelin repair by human and mouse oligodendrocyte progenitor cells

Jessie Polanco, R. Ross Welliver, Richard Seidman, Anjali Sinha, Melanie O’Bara, Zainab Khaku, Fraser Sim

 

 

IMSD grant renewal means $2.3 million for students from underrepresented groups

Posted on 05/15/17 at 10:15 am
Mentored Career Development Award Program Mid-Program Reflection, March 2017

A National Institutes of Health (NIH) training grant aimed at providing professional development resources and mentoring for doctoral students in several UB schools has been renewed for another five years.

The Initiative for Maximizing Student Development (IMSD) will provide $2.3 million in funding to train 20 new biomedical and behavioral scientists from underrepresented groups between now and 2021.
The institutional grant benefits doctoral students in the following schools and institutes: Jacobs School of Medicine and Biomedical Sciences, School of Dental Medicine, School of Pharmacy and Pharmaceutical Sciences, School of Public Health and Health Professions, College of Arts and Sciences, School of Engineering and Applied Sciences and Roswell Park Cancer Institute Graduate Division.

The Initiative for Maximizing Student Development (IMSD) will provide $2.3 million in funding to train 20 new biomedical and behavioral scientists from underrepresented groups between now and 2021.

The institutional grant benefits doctoral students in the following schools and institutes:

  • Jacobs School of Medicine and Biomedical Sciences
  • School of Dental Medicine
  • School of Pharmacy and Pharmaceutical Sciences
  • School of Public Health and Health Professions, College of Arts and Sciences
  • School of Engineering and Applied Sciences
  • Roswell Park Cancer Institute Graduate Division

“When you get an infusion of funds such as this, it provides the seed to energize everyone,” says Margarita L. Dubocovich, PhD, senior associate dean for diversity and inclusion, the principal investigator on the grant.

Read more here.

 

A look back, and ahead, at CTSI Annual Forum 2017

Posted on 05/15/17 at 10:03 am

The University at Buffalo Clinical and Translational Science Institute (CTSI) held its 2nd Annual Forum on March 28. Faculty, staff and stakeholders in the CTSI gathered in the Clinical and Translational Research Center (CTRC) to take stock of progress that’s been made so far and what needs to be done in the coming year.

Following opening remarks by Michael E. Caine, MD, Vice President for Health Sciences and Dean of the Jacobs School of Medicine and Biomedical Sciences (JSMBS), SUNY Distinguished Professor and CTSI Director Timothy F. Murphy, MD, provided an overview of recent accomplishments and what to expect in the third year of the NIH Clinical and Translational Science Award (CTSA), which was granted to UB in August of 2015.

Murphy talked about the transformation of clinical research at UB that has taken place since the CTSI was instituted, beginning with implementation of improved tracking of clinical studies system-wide, and a significant reduction in the amount of IRB approval time. He discussed the ongoing build-out of the Translational Imaging Center, the CTSI biorepository and research pharmacy. He said recruitment to clinical studies will get a big boost from the recent implementation of the new i2b2 platform, which will allow clinical researchers to make better use of electronic health data for feasibility studies and, with IRB approval, execution of recruiting strategies. The CTSI’s pilot studies program has seen a 13:1 return on investment since it was implemented in 2011, and is now able to allocate three times the funding as compared to earlier years because of the CTSA.

Murphy shared the following priorities for 2017-18:

  • Full implementation of the Clinical Trials Management System
  • Accelerated start-up of all clinical studies
  • Continued support and tracking of the Translational Pilot Studies Program
  • Continued expansion and growth of the Imaging Center, biorepository and research pharmacy
  • Expanded education and training programs
  • Active engagement in CTSA national consortium
  • Further opportunities for applying for CTSA U01 and R21 grants

Three CTSI Scholars were introduced by SUNY Distinguished Professor and Mentored Career Development Program Director Margarita L. Dubocovich, PhD. Presenting their research were: Nikhil Satchidanand, PhD, research assistant professor, Department of Family Medicine, JSMBS; Ellen Volpe, PhD, RN, assistant professor, School of Nursing; and Umesh Sharma, MD, assistant professor, Department of Medicine, JSMBS.

SUNY Distinguished Professor and Charles and Mary Bauer Professor and Chair, Department of Medicine, JSMBS, Anne B. Curtis, MD, chaired the inaugural UB Clinical Research Achievement Award session. She awarded certificates to four investigators who presented on their research published in major journals during 2016.

Presenting were:

Sebastian G. Ciancio, DDS, Distinguished Service Professor and chair, Department of Periodontics and Endodontics, School of Dental Medicine, “Anesthesia Given by Intranasal Mist”

Rina Das Eiden, PhD, senior research scientist, Research Institute on Addictions, “Cascade Model for Adolescent Substance Use”

Timothy F. Murphy, MD, “Effect of Antibiotics in COPD”

 Gil I. Wolfe, MD, professor and chair, Department of Neurology, JSMBS, “Randomized Trial of Thymectomy in Myasthenia Gravis.”

The half-day event concluded with “Advancing Creativity in Clinical and Translational Research,” a presentation by Larry W. Hawk, PhD, professor in the Department of Psychology, College of Arts and Sciences.

Nobel Prize winner shares life experiences with UB audience

Posted on 05/04/17 at 01:33 pm
Michael Levitt, PhD, Robert W. and Vivian K. Cahill Professor in Cancer Research, Stanford School of Medicine
An audience of about 300 people were on hand for the third 2016-17 CTSI Seminar Series lecture.

The University at Buffalo Jacobs School of Medicine and Biomedical Sciences welcomed a scientific celebrity to campus for the Clinical and Translational Science Institute (CTSI) Seminar Series/O.P. Jones Lecture on May 2. Michael Levitt, PhD, a biophysicist in the Stanford University School of Medicine, is considered one of the founders of computational biology. He was awarded the 2013 Nobel Prize in Chemistry, along with Martin Karplus and Arieh Warshel, for the development of multiscale models for complex chemical systems.

Levitt was the guest of the medical school’s Department of Biomedical Informatics. UB’s Ram Samudrala, PhD, chief of the department’s division of bioinformatics and a member of the CTSI informatics core faculty, was Levitt’s student at Stanford in the late ‘90s and early 2000s.

Levitt pioneered the use of computer models for examining the structure and function of molecules beginning in the late 1960s. His presentation on “The Birth and Future of Multiscale Modeling of Macromolecules” looked back on his storied career and served as an inspiration to students and faculty among the nearly 300 people who came out to Butler Auditorium to hear him speak.

Combining elements of his biography with developments in the field, Levitt described how translating some of the most fundamental formulas of physics into Fortran (an early computer coding language) allowed him and his early collaborators to form images of submicroscopic particles, such as proteins and amino acids. The state of the art at the time was to construct physical models out of tinker toy-like components. 

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