Laboratory Core Facilities

The Buffalo Translational Consortium offers an outstanding range of core laboratory facilities. They are housed in various BTC institutions and are available to researchers regardless of your institutional affiliation.

Below is a summary of the core facilities with links to each core.

You may contact Core Facilities directly through the links or if you would like guidance, please use our web portal at the "Request a CTSA Service" link above.

Laboratory Core Facilities

Genomics and Proteomics
Core Facility Description
Next Generation Sequencing and Expression Core Offers high-throughput, next-generation sequencing using the Roche/454, Illumina and Ion Torrent platforms. The Core also provides gene-expression analysis services, including 3'-expresion, miRNA, exon, and gene arrays on Affymetrix platforms.
Director:  Norma Nowak PhD
Location: UB New York State Center of Excellence in Bioinformatics and Life Sciences
Link: Click for full info
DNA (Sanger) Sequencing Lab Provides access to state-of-the-art biomolecular instrumentation and techniques. The core provides DNA sequencing and fragment analysis with rapid turnaround at a low cost to all investigators in the Buffalo Niagara Medical Campus.
Director: Sean T. Glenn, PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Genomic Shared Resource Resource services include next-generation sequencing using Illumina and Ion Torrent technology, as well as Illumina microarray platforms including methylation, SNP genotyping, and gene expression arrays. Further services using state-of-the-art equipment such as Nanostring nCounter, Bio-Rad ddPCR, Sequenom MassArray, and Fluidigm C1 single cell profiling are also available.
Director:  Sean T. Glenn, PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Proteomics/Mass Spectrocopy Core Specializes in ultrasensitive quantification of small-molecule drugs and other analytes and full range of proteomics research approaches including expression profiling, proteomic quantification and protein analysis.
Location: UB New York State Center of Excellence in Bioinformatics and Life Sciences
Director: Robert Straubinger PhD
Link: Click for full info

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Laboratory Animal Core Facilities
Core Facility Description
Comparative Medicine-Laboratory Animal Facility Centralized AAALAC certified facility responsible for the animal care and use program at UB. This facility ensures humane and appropriate animal care, assists principal investigators and their technical personnel, and ensures that the highest standards are met. Includes large and small animals.
Location: Clinical and Translational Research Center and School of Medicine and Biomedical Sciences
Director: Lisa Martin DVM, DACLAM
Link: Click for full info
Gene Targeting and Transgenic Facility Provides services to modify the murine genome by transgenic approaches for the systematic dissection of the genetic, molecular, cellular and physiological mechanisms underlying complex biological processes. The Gene Targeting and Transgenic Facility has the resources and skills necessary to construct mice with defined mutations at specific locations of the mouse genome by in vitro manipulation of embryonic stem (ES) cells by blastocyst injection of altered ES cells.
Location: Roswell Park Cancer Institute
Director:  Kenneth Gross PhD
Link: Click for full info
Laboratory Animal Resources The Laboratory Animal Resource is responsible for the support of biomedical research by promoting the humane care of laboratory animals at Roswell Park Cancer Institute.  The facility provides the entire spectrum of animal-related research services including but not limited to specialized animal husbandry, veterinary medical care, diagnostic services, irradiation services, imaging resources and training of investigators and laboratory personnel.
Location: Roswell Park Cancer Institute
Director: Sandra Sexton, DVM DACLAM

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Biorepositories and Tissue Specimens
Core Facility Description
Department of Social and Preventive Medicine Biological Specimen Bank Houses specimens collected as part of epidemiological studies and clinical trials conducted in SPM. The SPM bio-bank currently houses ~1 million samples from 25,000 participants.
Location: UB School of Public Health and Health Professions
Director: Jean Wactawski-Wende PhD
Link: Click for full info
Data Bank and BioRepository (DBBR) Prospectively collects and provides de-identified biospecimens and associated epidemiological and clinical data to meet the scientific needs of investigators.
Director: Christine Ambrosone PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Pathology Resource Network Provides human specimens and laboratory services for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall mission is to facilitate access to human tissue for investigators with IRB approval with an emphasis on translational efforts.
Director:  Carl Morrison MD, DVM
Location: Roswell Park Cancer Institute
Link: Click for full info
**CTRC Biobank The CTRC includes a biobank facility capable of storing 2 million specimens. The Biobank is being equipped using institutional resources. It is anticipated that the Biobank will be functional in 2015 . The service and specimens will available to BTC investigators. The CTRC Biobank will implement informatics and annotation using principled biomedical ontologies and will be designed to integrate with the Roswell Park and Department of Social and Preventive Medicine biorepositories.
Director: John Tomaszewski MD
Location: Clinical and Translational Research Center

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Immunology and Histology Core Facilities
Core Facility Description
Flow Cytometry and Cell Sorting Hosts analytical fluorescence-activated flow cytometers and state-of-the art high-speed cell sorters. Provides expert assistance and support services.
Director:  Wade J. Sigurdson PhD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info
Flow and Image Cytometry Resource Provides advanced flow cytometric and morphology service at cellular and subcellular levels of resolution.
Director: Paul Wallace, PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Histology Service Laboratory Full-service research histology laboratory.
Director: Peter Nickerson MD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info

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Microscopy and Imaging Facilities
Core Facility Description
Molecular and Translational Imaging Center This new imaging center in the CTRC provides advanced imaging facilities dedicated exclusively to translational research. Equipment includes PET/CT and 3T MRI (for human and large animals) and a 9.4T micro MRI for small animals.
Director: John Canty MD, Robert Zivadinov MD PhD
Location: Clinical and Translational Research Center
Link: Click for full info
Buffalo Neuroimaging Analysis Center The BNAC focuses on quantitative analysis of MRI for clinical research and structural and functional quantitative MR image analysis in humans and animals. Analyses include lesion/tumor identification, perfusion and DCE mapping and quantification, fluid flow quantification, functional MRI analysis, diffusion tensor reconstruction and tractography, voxel-wise mapping and image-based group statistical analysis, and tissue volumetry.
Director: Dr. Robert Zivadinov, MD, PhD
Location: Buffalo General Hospital
Link: Click for full info
Confocal Microscopy and Cellular Imaging Facility Provides Zeiss LSM-510 Meta NLO laser scanning confocal microscope capable of simultaneous imaging of multiple-emission wavelengths, transmitted-light imaging and multiphoton capability. Zeiss Axio Observer and Axioimager wide-field fluorescent microscopes are available for bright field, DIC and phase contrast imaging with cooled-CCD and color cameras. The service provides hands on training to researchers and trainees.
Director: Wade J. Sigurdson PhD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info
Translational Imaging Shared Resource Provides small animal imaging services to investigators. Imaging includes MRI (4.7T), bioluminescence imaging, whole body fluorescence imaging, near IR imaging, Xray imaging, custom image analysis and three dimensional visualization
Director: Mukund Seshadri PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Scanning Transmission X-ray Microscopy Scanning Transmission X-Ray Microscopy service. Secondary electron imaging of topographic features with magnification up to 100,000x and spatial resolution better than 50 Å; backscattered electron imaging of chemical phase difference; qualitative and quantitative elemental analysis with EDS; X-ray imaging: elemental line scans and maps.
Director: Peter Bush
Location: School of Dental Medicine
Link: Click for full info
Electron Microscopy Laboratory Transmission electron microscopy facility.
Director: Ted Szczesny
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info

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Drug Development and Pharmacology
Core Facility Description
BTC Drug Development Service* A centralized service that brings together the drug development expertise of Roswell Park and UB to provide a resource (including training) in preclinical and early clinical development of novel compounds.
*New core facility proposed as part of the CTSA application
Directors: Gene Morse PharmD, Andrei Gudkov PhD DSci
Location: UB School of Pharmacy and Pharmaceutical Sciences, Roswell Park Cancer Institute
Link: Click for full info
cGMP Facility Center for Immunotherapy Good Manufacturing Practices (GMP) Therapeutic Cell Production Facility consists of a class 100,000 anteroom (gowning and storage) and class 10,000 cell processing room (manufacture of cell therapy products for Phase I and Phase II clinical trials).
Location: Roswell Park Cancer Institute
Directors: Yeong Choi PhD and Adekunle Odunsi, MD PhD
Link: Click for full info
X-ray Crystallography Core/High-throughput Crystal Screening Laboratory Provides rapid screening using the microbatch-under-oil crystallization technique and enables crystallographic structure determination of a drug target. The high-throughput screening (HTS) laboratory performs crystal-growth screening experiments using automated liquid handling and imaging systems coordinated through a LIMS/database to quickly set up and record the outcomes of 1536 unique crystallization screening conditions.
Director: George DeTitta PhD
Location: Hauptman Woodward Research Institute
Link: Click for full info
Small Molecule Screening Core Facility Provide screening of chemical libraries in a variety of readout systems for new bioactive compounds, prospective therapeutics and research tools and potential therapeutic compounds.
Director: Mikhail Chernov PhD
Location: Roswell Park Cancer Institute
Link: Click for full info
Translational Pharmacology Research Core Provides services to investigators that include pre-clinical and clinical study design; analysis for pharmacokinetics, pharmacodynamics and pharmacogenomics; and drug assays.
Director: Gene Morse PharmD
Location: UB New York State Center of Excellence in Bioinformatics and Life Sciences
Link: Click for full info
Toxicology Research Center This multiuser facility houses instrumentation for conducting cellular, biochemical and molecular studies, including protocols for preclinical drug testing in support of New Drug Applications
Director: Paul Kostyniak PhD DABT
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info

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Stem Cell Core Facilities
Core Facility Description
Induced Pluripotent Stem Cell Generation Helps investigators generate induced pluripotent stem cells from human skin fibroblasts using lentiviral vectors.
Director: Jian Feng PhD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info
Stem Cell Culture, Banking and Training Maintains and banks stem cells, and provides stem cells and training to researchers.
Co-Directors: Michal Stachowiak, PhD and Richard Gronostajski, PhD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info
Stem Cell Engraftment and In Vivo Analysis Performs and analyzes the engraftment of a variety of stem cells in vivo, the effects of genetic modification of stem cells on engraftment and stem cell function, and the behavioral consequences of neural engraftment.
Director: Michal Stachowiak PhD
Location: UB School of Medicine and Biomedical Sciences
Link: Click for full info
Stem Cell Sequencing/Epigenomics Analysis Characterizes and identifies epigenetic and transcription signatures of stem cells and their derived progeny using Next-Gen sequencing.
Director: Michael Buck PhD
Location: UB New York State Center of Excellence in Bioinformatics and Life Sciences
Link: Click for full info

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